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Principal Investigator (Assistant, Associate or Full Staff) – Cardiovascular and Metabolic Sciences
Req#: 949336
Location:
Facilities: Cleveland Clinic
Professional Area: Physician
Department: Cardiology – Research
Schedule: Full Time
The Department of Cardiovascular and Metabolic Sciences, chaired by Dr. Stanley Hazen, MD, PhD, in the Lerner Research Institute at the Cleveland Clinic, seeks investigators who use multidisciplinary approaches to determine the underlying causes of and develop new treatments for cardiovascular diseases. We are seeking to expand and enhance our research efforts in the areas of cardio-metabolism, vascular biology, atherosclerosis, thrombosis, arrhythmia, and heart failure with an open search for NIH funded investigators at the Assistant, Associate, or Full Staff levels who will leverage existing expertise and clinical infrastructure for programmatic efforts. Candidates should have demonstrated expertise in mechanistic investigations and experimental systems that can include cellular, molecular, computational, animal model, and/or human clinical studies. The department is especially interested in qualified candidates who can contribute to the diversity and excellence of the academic community.
Individuals will be appointed at Assistant, Associate, or Full Staff (equivalent to Assistant, Associate, or Full Professor, respectively) in the Department of Cardiovascular and Metabolic Sciences (CVMS) in the Lerner Research Institute. For physician-scientists, joint appointments in clinical institutes will be made as appropriate. New recruits will join a highly collaborative environment within CVMS with additional opportunities for collaboration and networking within the Heart and Vascular Impact Area and in the over 25 Departments and Centers at the Lerner Research Institute (https://www.lerner.ccf.org/science/). Cleveland Clinic provides outstanding opportunities for interactions with basic, translational, and clinical investigators from multiple specialties. Outstanding facilities, generous start-up funds, and ongoing operational support will be provided. We have world-class core facilities with the opportunity to grow them through the substantial expansion of the Lerner Research Institute through the formation of the Global Center for Pathogen Research and Human Health.
The Lerner Research Institute, with nearly 190 independent investigators in over 25 Departments and Centers and an annual budget of ~ $300 million, has a commitment to excellence in basic, translational and clinical research, with an emphasis on collaborative science. Faculty typically also become members of the Molecular Medicine Graduate Training Program and other programs at the neighboring Case Western Reserve University School of Medicine, providing access to excellent PhD students and trainees.
Candidates should submit a complete curriculum vitae, brief statement of research interests, and names of 3 references by email to Alyssa Carmigiano: carmiga@ccf.org.
About Us
Cleveland Clinic’s vision is to become the best place for care and the best place to work in healthcare. We are committed to providing a safe, stable, and financially fulfilling work environment. Cleveland Clinic is ambitiously investing in growth. Being a physician-led organization means doing what is best for the patients, every day.
Cleveland Clinic is one of the world’s largest and busiest health centers. Patients come to Cleveland Clinic from all over the world. We offer advanced treatment for all illnesses and disorders of the body.
Cleveland Clinic is a nonprofit, multispecialty academic medical center that’s recognized in the U.S. and throughout the world for its expertise and care. Cleveland Clinic integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S. News & World Report consistently names Cleveland Clinic as one of the nation’s best hospitals in its annual America’s Best Hospitals survey. Among Cleveland Clinic’s 80,642 employees worldwide are more than 5,743 salaried physicians and researchers, and 20,166 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,690-bed health system that includes a 173-acre main campus near downtown Cleveland, 23 hospitals, more than 270 outpatient facilities, including locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2024, there were 14.1 million total outpatient visits, 333,000 hospital admissions and observations, and 320,000 surgical cases throughout Cleveland Clinic’s health system. Patients came for treatment from every state and 185 countries.
Our Culture
Cleveland Clinic is pleased to be an equal employment opportunity employer. Smoke/drug free environment.
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Please be advised that all information entered in your application will only be shared with Cleveland Clinic and will not be distributed to third parties.
The pay range displayed on this job posting reflects the anticipated range for new hires and is for a 100%, full-time employment (FTE). A successful candidate’s actual compensation will be consistent with fair market value and determined after taking various factors into consideration such as the candidate’s work history, experience, skill set, % of FTE and board certification. This is not inclusive of the value of Cleveland Clinic’s benefits package, which includes among other benefits, healthcare/dental/vision, and retirement.
About the Community
Cleveland is part of Northeast Ohio which is composed of six metropolitan areas. Each of them provides affordable real estate, excellent schools, safe communities as well as an abundance of outdoor activities. Find out here how great it is to live in Cleveland!
Information for Candidates
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Disclaimer
Cleveland Clinic Health System administers an influenza prevention program. You will be required to comply with the program, which will include obtaining an influenza vaccination or an exemption.
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Pay Range
Minimum salary: $130,000
Maximum salary: $300,000
Nursing Support Career Paths
Working for Cleveland Clinic is more than just a job – it can be a launching point for an exceptional career. Nursing Support plays a critical role in ensuring excellent care and positive patient experiences. There is a wide range of roles to contribute to this vital team. We are committed to providing you with the resources and support you need to define and follow your own unique career path, whether in Nursing Support or other areas of our organization. Nursing Support opportunities include:
Benefits Offerings
Our caregivers deliver the best outcomes for our patients across each of our facilities. We are committed to providing them with the kind of exceptional care they bring to our patients. Caregivers like you come to work each day with a passion for what you do. So, we are always focused on fueling that passion, empowering you to be your best both inside our hospitals and in your life. Our outstanding, comprehensive offerings are an investment in your health, well-being and future. Explore the following benefits and get a closer look at how we’re focused on what matters most to you.

We offer the following choices to cover your health, dental and vision care as well as life insurance.
- Health Plan Options – You have the choice between two comprehensive Cleveland Clinic Employee Health Plan options: EHP and EHP Plus. Both plans are administered by Aetna and feature minimal copays for in-network care. Although the benefit designs of EHP and EHP Plus are identical, they differ in their provider network size, with EHP offering a narrow network and EHP Plus providing access to the wide Aetna Open Access Select network. Both plans include access to Cleveland Clinic providers. The health plan also offers Healthy Choice, a voluntary program where participants earn premium discounts for achieving wellness goals.
- Dental Care – Four plan options administered by Cigna are available.
- Vision Care – Two plan options administered by EyeMed are available.
- Flexible Spending Accounts – Healthcare and Dependent Care FSAs are available to help you pay for eligible expenses with pre-tax dollars.
- Life Insurance – Employer-paid life insurance equals 1x your annual salary with an option to purchase supplemental life insurance up to 10x your salary. You may also purchase dependent life insurance for a spouse and dependent children
- Short- and Long-term Disability Coverage – Short-term disability is available after one continuous year of regular full-time service; long-term disability begins after 90 days.

Because financial security is essential to a secure retirement, we sponsor a comprehensive retirement program to help you build for your financial future:
- Cleveland Clinic Investment Pension Plan offers eligible employees an excellent opportunity to build a retirement account for the future. It is fully funded by Cleveland Clinic and equal to 2.5% of your salary (increasing with more years of service).
- The 401(k) / 403(b) Plan also provides an important source of retirement savings. It allows participants to take responsibility for their financial future by making retirement savings a part of their normal routine while working. In addition to your contributions to the plan, Cleveland Clinic matches a portion of your contributions (50% on up to your first 6% in contributions).

- Paid Time Off (PTO) – Eligible caregivers receive Paid Time Off (PTO) that can be allotted toward vacation, holidays, sick time, etc.
- Caregiver discounts – We offer discounted rates for auto, home and pet insurance, identify theft protection and more.
- Adoption assistance – We provide financial assistance of up to $5,000/per child ($10,000 maximum lifetime benefit) for caregivers who choose to legally adopt a child.
- Employee Assistance Program – The Program provides free, confidential short-term counseling for caregivers and their families, whether for relationships or legal challenges.
- Employee Hardship Fund – This fund provides aid for caregivers experiencing unexpected financial difficulties.
- Paid maternity and parental leave – You will enjoy up to eight consecutive weeks for maternal care after the birth of your child to bond with your baby and up to four weeks for parental care.


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The policy of Cleveland Clinic Health System and its system hospitals (Cleveland Clinic Health System) is to provide equal opportunity to all of our caregivers and applicants for employment in our drug-free environment. All offers of employment are followed by testing for controlled substances.
Cleveland Clinic Health System administers an influenza prevention program. You will be required to comply with this program, which will include obtaining an influenza prevention program. You will be required to comply with this program, which will include obtaining an influenza vaccination on an annual basis or obtaining an approved exemption.