Our translational laboratory is dedicated to bridging the gap between bench and bedside by developing innovative cellular immunotherapies for children and young adults with gliomas and other CNS tumors. We are particularly focused on integrating personalized medicine and immunotherapy as an addition to the standard of care to improve survival and quality of life for our patients.
Principal Investigator: Prajwal Rajappa, MD, MS
Cleveland Clinic Research Department: Center for Immunotherapy and ImmunoOncology
Lab Research Topics:
- Pediatric and Adolescent and Young Adult (AYA) brain cancer
- Glioma and Central nervous system (CNS) tumor and immune biology
- Innate (myeloid) and adaptive immunity within the glioma immune microenvironment
- Personalized medicine
- Cellular immunotherapy
- For more information about the lab’s research, please contact Dr. Rajappa at rajappp@ccf.org.
Job Responsibilities:
- Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation
- Conduct translational research focused on Pediatric and Adolescent and Young Adult (AYA) Gliomas and Central Nervous System tumors
- Design and implement cellular immunotherapy strategies to prevent glioma progression
- Develop and evaluate personalized medicine approaches to complement standard of care
- Leverage unique human and mouse archival tissues to advance research and clinical impact
Education:
- PhD or MD/PhD required
- MD with relevant laboratory experience may substitute for PhD
Languages:
- English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status
Work Experience:
- Previous experience in a research or academic setting. Graduate student experience meets this requirement.
- Scientific writing experience
Additional Preferred Qualities:
- Strong background in cancer biology or tumor immunology
- Experience with molecular biology techniques and mouse modeling (in-vivo handling and treatment studies in mouse tumor model systems)
- Experience with multi-parameter flow cytometry, myeloid, NK, and T cell-based assays for human and mouse samples
- Experience working with the interpretation of next-generation sequencing data
- Strong publication record in addition to excellent communication and teamwork skills
Physical Requirements:
- Ability to perform work in a stationary position for extended periods
- Ability to operate a computer and other office equipment
- Ability to communicate and exchange accurate information
- Ability to distinguish color
- Manual dexterity to handle specimens and repair equipment
- Ability to lift and transport equipment or specimens weighing up to 20 pounds
- May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.
Personal Protective Equipment:
- PPE per institutional requirements; may vary by laboratory
Preferred Application Materials:
- CV
- Research statement
- References list
- All application materials should be submitted directly via email to Prajwal Rajappa at rajappp@ccf.org.
Keywords: Postdoc, Research, LRI, Pediatric Oncology, CNS Tumors, Personalized Medicine, Immunotherapy, Glioma, Translational Research, Tumor Microenvironment, Myeloid based Therapy, Single-cell Sequencing, Neuro-oncology, Cancer Genomics, Precision Medicine, Immuno-oncology, Cell Therapy, Translational Medicine
Pay Range
Minimum Annual Salary: $31,200.00
Maximum Annual Salary: $312,000.00
The pay range displayed on this job posting reflects the anticipated range for new hires. A successful candidate’s actual compensation will be determined after taking factors into consideration such as the candidate’s work history, experience, skill set and education. The pay range displayed does not include any applicable pay practices (e.g., shift differentials, overtime, etc.). The pay range does not include the value of Cleveland Clinic’s benefits package (e.g., healthcare, dental and vision benefits, retirement savings account contributions, etc.).
Decisions concerning employment, transfers and promotions are made upon the basis of the best qualified candidate without regard to color, race, religion, national origin, age, sex, sexual orientation, marital status, ancestry, status as a disabled or Vietnam era veteran or any other characteristic protected by law. Information provided on this application may be shared with any Cleveland Clinic Health System facility.
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